Toxin-Antitoxin Pairs in Bacteria Killers or Stress Regulators?
نویسندگان
چکیده
Plasmid toxin-antitoxin systems, which kill daughter cells that fail to inherit the plasmid genome, have chromosomal homologs in eubacteria and archaea. In this issue of Cell, Pederson et al. show that the E. coli RelE toxin cleaves mRNA in the ribosomal A site, potentially allowing it to function as a stress regulator during amino acid starvation.
منابع مشابه
Prokaryotic toxin-antitoxin systems--the role in bacterial physiology and application in molecular biology.
Bacteria have developed multiple complex mechanisms ensuring an adequate response to environmental changes. In this context, bacterial cell division and growth are subject to strict control to ensure metabolic balance and cell survival. A plethora of studies cast light on toxin-antitoxin (TA) systems as metabolism regulators acting in response to environmental stress conditions. Many of those s...
متن کاملEvaluation of Toxin and Antitoxin System in Acinetobacter Multidrug Resistance Bacteria Isolated From Clinical Specimens
Introduction: Acinetobacter baumannii is one of the most important nosocomial and community-acquired pathogens that is resistant to many antibiotics. Toxin-antitoxin systems are regulatory systems that maintain bacteria and serve as new targets for Antimicrobial therapies are considered. The prevalence and transcription of these systems in clinical isolates is still unknown. The aim of this stu...
متن کاملIdentification and characterization of chromosomal relBE toxin-antitoxin locus in Streptomyces cattleya DSM46488
The relBE family of Type II toxin-antitoxin (TA) systems have been widely reported in bacteria but none in Streptomyces. With the conserved domain searches for TA pairs in the sequenced Streptomyces genomes, we identified two putative relBE loci, relBE1sca and relBE2sca, on the chromosome of Streptomyces cattleya DSM 46488. Overexpression of the S. cattleya toxin RelE2sca caused severe growth i...
متن کاملThe vapB–vapC Operon of Acidovorax citrulli Functions as a Bona-fide Toxin–Antitoxin Module
Toxin-antitoxin systems are commonly found on plasmids and chromosomes of bacteria and archaea. These systems appear as biscystronic genes encoding a stable toxin and a labile antitoxin, which protects the cells from the toxin's activity. Under specific, mostly stressful conditions, the unstable antitoxin is degraded, the toxin becomes active and growth is arrested. Using genome analysis we ide...
متن کاملChaperone addiction of toxin–antitoxin systems
Bacterial toxin-antitoxin (TA) systems, in which a labile antitoxin binds and inhibits the toxin, can promote adaptation and persistence by modulating bacterial growth in response to stress. Some atypical TA systems, known as tripartite toxin-antitoxin-chaperone (TAC) modules, include a molecular chaperone that facilitates folding and protects the antitoxin from degradation. Here we use a TAC m...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید
ثبت ناماگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید
ورودعنوان ژورنال:
- Cell
دوره 112 شماره
صفحات -
تاریخ انتشار 2003